Приложение 2. Список общепринятых корневых основ

Приложение 2

Список общепринятых корневых основ (stems), используемых при отборе МНН

Основа (STEM)	Перевод	Определение (субоснова, если имеется)
-ас*	-ак	anti-inflammatory agents, ibufenac derivatives
-actide	-актид	synthetic polypeptides with a corticotropin-like action
-adol or -adol-	-адол или -адол-	analgesics
-adom	-адом	analgesics, tifluadom derivatives
-afenone	-афенон	antiarrhythmics, propafenone derivatives
-aj-	-ай	antiarrhythmics, ajmaline derivatives
-aldrate	-алдрат	antacids, aluminium salts
-alox	-алокс	antacids, aluminium derivatives
-amivir	-амивир	см. vir
andr or -stan- or -ster-	андр или -стан- или -стер-	steroids, androgens
-anserin	-ансерин	serotonin receptor antagonists (mostly 5-НТ_2)
-antel	-антел	anthelmintics (undefined group)
-apine	-апин	см. -pine
-arabine	-арабин	arabinofuranosyl derivatives
-arit	-арит	antiarthritic substances, acting like clobuzarit and lobenzarit (mechanism different from anti-inflammatory type substances, e.g. -fenamates or -profens)
-arol	-арол	anticoagulants, dicoumarol derivatives
arte-	арт-	antimalarial agents, artemisinin related compounds
-ase	-аза	enzymes; - dismase (superoxide dismutase activity), - pase (lipase) - teplase (tissue plasminogen activators), - uplase (urokinase-type-plasminogen activators)
-ast	-аст	antiasthmatic, antiallergics, not acting primarily as antihistaminics; - lukast (leukotriene receptor antagonist); - trodast (thromboxane A_2 receptor antagonists, antiasthmatics)
-astine	-астин	antihistaminics
-azenil	-азенил	benzodiazepine receptor antagonists/agonists (benzodiazepine derivatives)
-azepam	-азепам	diazepam derivatives
-azepide	-азепид	cholecystokinin receptor antagonist
-azocine	-азозин	narcotic antagonists/agonsists related to 6,7-benzomorphan
-azoline	-азолин	antihistamines or local vasoconstrictors, antazoline derivatives
-azosin	-азосин	antihypertensive substances, prazosin derivatives
-bactam	-бактам	b-lactamase inhibitors
-bamate	-бамат	tranquillizers, propanediol and pentanediol derivatives
barb	барб	hypnotics, barbituric acid derivatives
-bendazole	-бендазол	anthelmintics, tiabendazole derivatives
bol	бол	anabolic steroids
-bradine	-брадин	bradycardic agents
-buzone	бузон	anti-inflammatory analgesics, phenylbutazone derivatives
-cain-	-каин-	Class I antiarrhythmics, procainamide and lidocaine derivatives (antifibrillants with local anaesthetic activity)
-caine	-каин	local anaesthetics
calci	кальци	Vitamin D analogues/derivatives
-carbef	-карбеф	antibiotics, carbacepham derivatives
-carnil	-карнил	benzodiazepine receptor antagonists/agonists (carboline derivatives)
-cavir	-кавир	см. vir
cef-	цеф-	antibiotics, cefalosporanic acid derivatives
cell- or cel- or -cell-	цел- или цел- или - цел-	cellulose derivatives cell-ate (cellulose ester derivatives); -cellose (cellulose ether derivatives)
-cic	-цик	hepatoprotective substances with a carboxylic acid group
-cidin	-цидин	naturally occurring antibiotics (undefined group)
-cillin	-цилин	antibiotics, 6-aminopenicillanic acid derivatives
-citabine	-цитабин	nucleoside antiviral or antineoplastic agents, cytarabine or azarabine derivatives
-clone	-клон	hypnotic tranquillizers
-cog	-ког	blood coagulation factors; (-)eptacog (blood coagulation VII); (-)octocog (blood coagulation factor VIII); (-)nonacog (blood coagulation factor IХ)
-conazole	-коназол	systemic antifungal agents, miconazole derivatives
cort	корт	corticosteroids, except prednisolone derivatives
-crinat	-кринат	diuretics, etacrynic acid derivatives
-crine	-крин	acetylcholinesterase inhibitors, tacrine derivatives
-cromil	-кромил	antiallergics, cromoglicic acid derivatives
-curium	-курий	см. -ium (ий)
-cycline	-циклин	antibiotics, tetracycline derivatives
-dan	-дан	cardiac stimulants, pimobendan derivatives
-dapsone	-дапсон	antimycobacteriais, diaminodiphenylsulfone derivatives
-dermin	-дермин	см. -ermin
-dil	-дил	vasodilators
-dipine	-дипин	calcium channel blockers, nifedipine derivatives
-dismase	-дисмаза	см. - ase (аза)
-dopa	-допа	dopamine receptor agonists, dopamine derivatives, used as antiparkinsonism/prolactm inhibitors;
-dox	-докс	antibacterial, quinoline dioxide derivatives
-dralazine	-дралазин	antihypertensives, hydrazinephthalazine derivatives
-drine	-дрин	sympathomimetics; - frine; sympathomimetic, phenethyl derivatives
-dronic acid	-дроник ацид	calcium metabolism regulator, pharmaceutical aid
-ectin	-эктин	antiparasitics, ivermectin derivatives
-entan	-энтан	endothelin receptor antagonists
-eptacog	-эптаког	см. -cog (кoг)
erg	эрг	ergot alkaloid derivatives
-eridine	-эридин	analgesics, pethidine derivatives
-ermin	-эрмин	growth factors; - dermin (epidermal growth factors); - fermin (fibrinoblast growth factors); - nermin (tumour necrosis factor); - sermin (insulin-like growth factors)
estr	эстр	estrogens
-etanide	-этанид	diuretics, piretanide derivatives
-exakin	-эксакин	см. -kin
-exine	-эксин	mucolytic, bromhexine derivatives
-fenamic acid	-фенамик ацид	antiinflammatory, anthranilic acid derivatives - fenamale ("-fenamic acid" derivatives)
-fenin	-фенин	diagnostic aids; (phenylcarbamoyl)methyl iminodiacetic acid derivatives
-fenine	-фенин	analgesics, glafenine derivatives - (subgroup of fenamic acid group)
-fentanil	-фентанил	narcotic analgesics, fentanil derivatives
-fermin	-фермин	см. -ermin
-fiban	-фибан	fibrinogen receptor antagonists (glycoprotein lIb/IIIа receptor antagonists)
-fibrate	-фибрат	clofibrate derivatives
-flapon	-флапон	5-lipoxygenase-activating protein (FLAP) inhibitor
-flurane	-флуран	general inhalation anaesthetics, halogenated alkane derivatives
-formin	-формин	antihyperglycaemics, phenformin derivatives
-fos (-vos)	-фос (-вос)	insecticides, anthelmintics, pesticides etc., phosphorous derivatives
-fos- or fos-	-фос- или фос-	various pharmacological categories belonging to -fos (other than above)
-fradil	-фрадил	calcium channel blockers acting as vasodilators
-frine	-фрин	см. -drine
-fungin	-фунгин	antifungal antibiotics
-fylline	-филлин	N-methylated xanthine derivatives
gab	габ	gabamimetic agents
gado-	гадо-	diagnostic agents, gadolinium derivatives
-gatran	-гатран	thrombin inhibitor, antithrombotic agents
gest	гест	steroids, progestogens
-giline	-гилин	MAO-inhibitors type В
-gillin	-гиллин	antibiotics produced by Aspergillus strains
gli	гли	antihyperglycaemics, sulfonamide derivatives
-golide	-голид	dopamine receptor agonists, ergoline derivatives
-gramostim	-грамостим	см. -stim
-grastim	-грастим	см. -stim
-grel- or -grel	-грел- или -грел	platelet aggregation inhibitors
guan-	гуан-	antihypertensives, guanidine derivatives
-icam	-икам	anti-inflammatory, isoxicam derivatives
-ifene	-ифен	antiestrogens, domifene and tamoxifen derivatives
-ilide	-илид	Class III antiarrhythmics, sematilide derivatives
imex	имекс	immunostimulants
-imod	-имод	immunomodulators, both stimulant/suppressive and stimulant
-imus	-имус	immunosuppressants {other than antineoplastics)
io-	йо-	iodine-containing contrast media
-io- or iod-	-йо- или йод-	iodine containing compounds other than contrast media
-iptan	-иптан	serotonin (5HT,) receptor agonists, sumatriptan derivatives
-irudin	-ирудин	hirudin derivatives
-isomide	-изомид	antiarrhythmics, disopyramide derivatives
-ium	-ий	quaternary ammonium compounds; -curium (curare-like substances)
-izine	-изин	diphenylmethyl piperazine derivatives; -rizine {antihistaminics/cerebral (or peripheral) vasodilators)
-kacin	-кацин	antibiotics, kanamycin and bekanamycin derivatives (obtained from Streptomyces kanamyceticus);
-kalant	-калант	potassium channel blockers
-kalim	-калим	potassium channel activators, antihypertensive
-kef-	-кеф-	enkephalin agonists
-kin	-кин	interleukin type substances; -nakin (II-1 derivatives) -leukin (II-2 derivatives) -plestim (II-3 derivatives) -exakin (II-6 derivatives)
-kinra	-кинра	interleukin receptor antagonists; -nakinra (II-1 receptor antagonists)
-kiren	-кирен	renin inhibitors
-leukin	-лейкин	см. -kin
-lipastat	-липастат	см. -stat
-lukast	-люкаст	см. -ast
-mab	-маб	monoclonal antibodies (более подробно на стр...)
-mantadine	-мантадин	adamantane derivatives; - mantine, -mantone
-meline	-мелин	cholinergic agents, arecoline derivatives
-mer	-мер	polymers
-mesine	-мезин	sigma receptor ligands
-mestane	-местан	aromatase inhibitors
-metacin	-метацин	ant-inflammatory, indometacin derivatives
-micin	-мицин	antibiotics obtained from various Micromonospora.
-monam	-монам	monobactam antibiotics
-morelin	-морелин	см. -relin
-mostim	-мостим	см. -stim
-motine	-мотин	antivirals, quinoline derivatives
-moxin	-моксин	monoamine oxidase inhibitors, hydrazine derivatives not part of definition
-mustine	-мустин	antineoplastic, alkylating agents, (b-hloroethyl)amine derivatives
-mycin	-мицин	antibiotics, produced by Streptomyces strains
nab	наб	cannabinol derivatives
-nakin	-накин	см. -kin
-nakinra	-накинра	см. -kinra
nal-	нал-	narcotic antagonists/agonists related to normorphine
-nercept	-нерцепт	tumor necrosis factor antagonist
-nermin	-нермин	см. -ermin
nic	ник	nicotinic acid or nicotinoyl alcohol derivatives
-nicate	-никат	antihypercholesterolaemic and/or vasodilating nicotinic acid esters
-nidazole	-нидазол	antiprotozoals, metronidazole derivatives
nifur-	нифур-	5-nitrofuran derivatives
-nixin	-никсин	anti-inflammatory, anilinonicotinicacid derivatives
-nonacog	-нонаког	см. -cog
-octocog	-октоког	см. -cog
-olol	-олол	b-adrenoreceptor antagonists; -alol: aromatic ring -CH-CH2-NH-R related to -oiols
-olone	-олон	steroids other than prednisolone derivatives
-opamine	-опамин*	dopaminergic agents dopamine derivatives used as cardiac stimulant/anti hypertensives/diuretics
-onide	-онид	steroids for topical use, acetal derivatives
-(o)nidine	-(о)нидин	antihypertensives, clonidine derivatives
-orex	-орекс	anoretics
orphan	орфан	narcotic antagonists/agonists, morphinan derivates; -orphine, -orphinol, orphone
-oxacin	-оксацин	antibacterials, nalidixic acid derivatives
-oxan(e)	-оксан	benzodioxane derivatives
-oxanide	-оксанид	antiparasitics, salicylanides and analogues
-oxef	-оксеф	antibiotics, oxacefalosporanic acid derivatives
-oxetine	-оксетин	antidepressants, fluoxetine derivatives
-pafant	-пафант	platelet-activating factor antagonists
-pamide	-памид	diuretics, sulfamoylbenzoic acid derivatives
-pamil	-памил	coronary vasodilators, verapamil derivatives
-parcin	-парцин	glycopeptide antibiotics
-parin	-парин	heparin derivatives including low molecular mass heparins
-penem	-пенем	analogues of penicillanic acid antibiotics modified in the five-membered ring
-peridol	-перидол	см. -perone
-peridone	-перидон	см. -perone
-perone	-перон	tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives; -peridot (antipsychotics, haloperidol derivatives); -peridone (antipsychotics, risperidone derivatives)
-pidem	-пидем	hypnotics/sedatives, Zolpidem derivatives
-pin(e)	-пин	tricyclic compounds; -apine (psychoactive); -cilpine(antiepileptic); -dipine (см. -dipine) -zepine (antidepressant/neuroleptic); -oxepin, -oxopine, -sopine, -tepines
-piprazole	-пипразол	psychotropics, phenylpiperazine derivatives
-pirox	-пирокс	antimycotic pyridone derivatives
-planin	-планин	antibacterial (Actinoplanes)
-platin	-платин	antineoplastic agents, platinum derivatives
-plestim	-плестин	см. -stim
-plon	-плон	Pyrazol[]pyrimidine derivatives, used as anxiolytics, sedatives, hypnotics -poetin erythropoietin type blood factors -porfin benzoporphyrin derivatives
-pramine	-прамин	substances of the imipramine group
-prazole	-празол	antiulcer, benzimidazole derivatives
pred	пред	prednisone and prednisolone derivatives; - methasone or -metasone, - betasol
-pressin	-прессин	vasoconstrictors, vasopressin derivatives
-pride	-прид	sulpiride derivatives
-pril(at)	-прил(ат)	angiotensin-converting
-pril(at)	-пpил(ат)	angiotensin-converting enzyme inhibitors
-prim	-прим	antibacterials, trimethoprim derivatives
-profen	-профен	anti-inflammatory agents, ibuprofen derivatives
prost	прост	prostaglandins; -prostil (prostaglandins, anti-ulcer)
-prostil	-простил	см. -prost
-quinil	-квинил	benzodiazepine receptor partial agonists (quinoline derivatives)
-racetam	-рацетам	amide type nootrope agents, piracetam derivatives
-relin	-релин	prehormones or hormone-release stimulating peptides: -morelin (growth hormone release-stimulating peptides); -tirelin (thyrotropin releasing hormone analogues)
-relix	-реликс	hormone-release inhibiting peptides
-renone	-ренон	aldosterone antagonists, spironolactone derivates
-restat (or -restat-)	-рестат (или -рестат-)	см. -stat
retin	ретин	retinol derivatives
-ribine	-рибин	ribofuranil-derivatives of the pyrazofurin type
rifa-	рифа-	antibiotics, rifamycin derivatives
-rinone	-ринон	cardiac stimulants, amrinone derivatives
-rizine	-ризин	см. -izine
-rozole	-розол	aromatase inhibitors, imidazole-triazoie derivatives
-rubicin	-рубицин	antineoplastic antibiotics, daunorubicin derivatives
sal	сал	salicylic acid derivatives: -sal-, salazo-, -salazine/salazide, -salan
-sartan	-сартан**	angiotensin II receptor antagonists, antihypertensive (nonpeptidic)
-semide	-семид	diuretics, furosemide derivatives
-sermin	-сермин	см. -ermin
-serpine	-серпин	derivatives of Rauwolfia alkaloids
-setron	-сетрон	serotonin receptor antagonists (5-НТ_3) not fitting into other established groups of serotonin receptor antagonists
som-	сом-	growth hormone derivatives
-spirone	-спирон	anxiolytics, buspirone derivatives
-stat (or -stat-)	-стат (или -стат-)	enzyme inhibitors: -lipastat (pancreatic lipase inhibitors); -restator -restat- (aldose-reducing inhibitors); -vastatin (antilipidemic substances, HMC CoA reductase inhibitors)
-steine	-стейн	mucolytics, other than bromhexine derivatives
-ster-	-стер	androgens/anabolic steroids: -testosterone, -sterone, -ster-, -gesterone, -sterone, sterol, ster, -(a)steride (antineoplastics)
-stim	-стим	colony stimulating factors: -grastim {granulocyte colony stimulatory factor (G-C5F) type) substances; -gramostim (granulocyte macrophage colony stimulating factor (CM-CSF) type substances); -mostim (macrophage stimulating factors (M-C5F) type substances); -plestim (interleukin-3 analogues and derivatives)
sulfa-	сульфа-	anti-infectives, sulfonamides
-sulfan	-сульфан	antineoplastic, alkylating agents, methanesulfonates
-tecan	-текан	antineoplastics, topoisomerase I inhibitors
-tepa	-тепа	antineoplastics, thiotepa derivatives
-teplase	-теплаза	см. -ase
-terol	-терол	bronchodilators, phenethylamine derivatives [previousty -prenaline or -terenol]
-terone	-терон	antiandrogens
-tiazem	-тиазем	calcium channel blockers, diltiazem derivatives
-tide	-тид	peptides and glycopeptides (for special groups of peptides см. -actide, -pressin, -relin, -tocin)
-tidine	-тидин	histamine H-receptor antagonists, cimetidine derivatives
-tirelin	-тирелин	см. -relin
-tizide	-тизид	diuretics, chlorothiazide derivatives
-tocin	-тоцин	oxytocin derivatives
-toin	-тоин	antiepileptics, hydantoin derivatives
-trexate	-трексат	folic acid analogues
-tricin	-трицин	antibiotics, polyene derivatives
-triptyline	-триптилин	antidepressants, dibenzo[a,d]cycloheptane or cyciopheptene derivatives
-troban	-тробан	thromboxane A_2-receptor antagonists; antithrombotic agents
-trodast	-тродаст	cu. -ast
trop	троп	atropine derivatives
-uplase	-уплаза	см. -ase
-uracil	-урацил	uracil derivatives used as thyroid antagonists and as antineoplastics
-uridine	-уридин	uridine derivatives used as antiviral agents and as antineoplastics; also -udine
-vastatin	-вастатин	см. -stat
-verine	-верин	spasmolytics with a papaverine-like action
vin- or -vin-	винили -вин-	vinca alkaloids
vir	вир	antivirals (undefined group); -amivir (neuraminidase inhibitors); -cavir (carbocyclic nucleosides); -virsen (antisense oligonucleotides)
-virsen	-вирсен	см. vir
-vudine	-вудин	antiviral; antineoplastics, zidovudine derivatives
-xanox	-ксанокс	antiallergic respiratory tract drugs, xanoxic acid derivatives
-zafone	-зафон	alozafone derivatives
-zepine	-зепин	см. -pine

______________________________

* В российской практике часто встречается основа "dopamine" - "допамин"

** Есть лекарство "лозартан"

Примечание:

Дефис (-) указывает на расположение корневых основ в МНН (спереди, на конце или в середине).

Отсутствие дефиса означает, что корневая основа может находиться в любом месте в МНН.

Список общепринятых корневых основ, которые больше не используются в МНН

Основа (STEM)	Перевод	Определение
mer- or -mer-	мер- или -мер-	mercury-containing drugs, antimicrobial or diuretic(deleted from General Principles in List 28 prop. INN)
mito-	мито-	antineoplastics, nucleotoxic agents (deleted from General Principles in List 24 prop- INN)
-ol	-ол	alcohols and phenols(deleted from General Principles in 14th report)
-quine, quin	-квин, квин	quinoline derivatives (deleted from General Principles in List 28 prop. INN)
-stigmine	-стигмин	anticholinesterases(deleted from General Principles in List 24 prop. INN)